Cytogenetic investigation of four low grade gliomas

Four low-grade gliomas - two oligodendrogliomas and two astrocytomas - were analyzed cytogenetically. All cases exhibited monosomies of chromosomes 10 and 11. The astrocytomas shared monosoniies of chromosomes 8, 9, 1O, 11, 12, 18 and 20. Losses of chromosomes 3, 5, 6, 10 and I I were present in both oligodendrogliomas, and except for monosomy of chromosome 6, were also identified in the pilocytic astrocytoma.